Dimethylbenzoylsulfanilamide. In vitro action and specificity

Abstract

The concentration of Sulfanilamide, Sulphathiazole and Irgafen necessary to prevent in vitro and completely the development of the Staphylococcus aureus during 24 hours and in 100 % of the cases was determined.

By concentrations of Sulfanilamide up to 1000 mgm. % a bacteriostasis of the defined type was never obtained being necessary to that object 475 mgm. % of Sulphathiazole and 185 mgm. % of Irgafen.

The results are shown in a graphic statistics and enables to obtain curves of action whose importance is discussed above all in connection with the controversy of the specifity of sulphonamides. As regards this, the most recent contributions of theoric chemistry are mentioned.

The commonly used methods of valuation of the bacteriostatic concentration is also object of criticism.

The technics is discussed as well as the synergism between heat and Sulphonamides to which knowledge new experimental data are produced.