Urinary excretion of endogenous digitalis-like natriuretic substances in healthy subjects. Effect of sodium load

M. Asbert
W. Jiménez
G.La Villa
J. Clària
C. López
P. Ginés
J. Gaya
A. Castro
F. Rivera
V. Arroyo
76

Abstract

In the current study digoxin-like immunoreactivity (DLIA), Na-K-ATPase inhibition and natriuretic activity of urinary extracts from 10 healthy volunteers following a low and a high-sodium intake, respectively, were measured. Detectable urinary DLIA (46.1 +/- 5.6 ng eq digoxin/day), Na-K-ATPase inhibition (182.9 +/- 22.7 nmol eq oub/day) and natriuretic activity (UNaV: 0.38 +/- 0.11 microEq/min) were observed during the low-sodium diet period in all subjects. High-sodium diet was associated with a significant increase in DLIA (87.9 +/- 9.2 ng eq digoxin/day, p less than 0.001) which parallelled changes in Na-K-ATPase inhibition (359.8 +/- 51.9 nmol eq oub/day, p less than 0.005) and natriuretic activity (UNaV: 1.33 +/- 0.3 microEq/min, p less than 0.025). These results support the contention that DLIA is related to NH.

Keywords:
Adult, Aldosterone/blood, Animals, Atrial Natriuretic Factor/blood, Blood Pressure/drug effects, Dietary/pharmacology, Digitalis Glycosides, Female, Glomerular Filtration Rate/drug effects, Humans, Inbred Strains, Male, Natriuresis/drug effects, Natriuretic Agents/pharmacology/urine, Norepinephrine/blood, Rats, Renin/blood, Sodium, Sodium-Potassium-Exchanging ATPase/antagonists and inhibitors, Sodium/pharmacology

Authors

M. Asbert
W. Jiménez
G.La Villa
J. Clària
C. López
P. Ginés
J. Gaya
A. Castro
F. Rivera
V. Arroyo


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