Projections from lamina V of the cerebral cortex to the dorsomedial thalamic nucleus and neighboring nuclei

Abstract
The laminar projections from the cerebral cortex to the mediodorsal thalamic nucleus and adjacent thalamic nuclei were studied by means of the horseradish peroxidase (HRP) retrograde axonal transport method. A possible correlation was found between the connectivity arising from layer V of the cerebral cortex, and the rich-acetylcholinesterase (AChE) regions within the subcortical structures under study. This suggests the possibility that layer V of the cerebral cortex in Alzheimer's disease is initially affected and subsequently those rich-AChE subcortical regions with which it is connected.
Keywords:
Acetylcholinesterase/analysis, Animals, Axonal Transport, Cats, Cerebral Cortex/anatomy and histology/enzymology, Efferent Pathways/anatomy and histology/chemistry, Horseradish Peroxidase, Nerve Tissue Proteins/analysis, Thalamic Nuclei/anatomy and histology/chemistry
Authors
Issue
Section
Articles