Effect of 6-hydroxydopamine intracerebrally injected on reproduction in rats

Abstract

The effect of 6-hydroxidopamine (6-OH-DA) –250 mug– intracerebrally injected on rat ovulation has been studied. Administration of 6-OH-DA in the nucleus accumbens septi and its heigbhourhood, inhibited follicle rupture, causing ovarian cycles with leucocitary phases in nearly all cases. The ovaries present a deep lutteynitation. Administration of 6-OH-DA in the strio-hypothalamic tract gives rise to a estrogenic cycle and to a normal number of oocytes in the tubes. The study of the fibrillar degeneration leads us to assumption of a probable adrenergic connections of the nucleus accumbens septi with the lateral hypothalamic area, preoptic area and olfactory tubercule. The influence of the nucleus accumbens septi on the mechanisms of follicle rupture is stressed.