Correlations of the levels of HbA1c with plasma apoproteins and plasma lipoproteins in type II diabetic patients

Abstract

Plasma apolipoproteins from VLDL, LDL and HDL lipoproteins were measured in 56 male patients with age range 50-60 years and noninsulin-dependent diabetes mellitus (type II) and 81 normal volunteers. Diabetic patients were further divided into two subgroups according to the HbA1c (glycated haemoglobin) concentrations, lower than 7% and higher than 7% respectively, after considering that HbA1c levels may be an appropriate index to monitor long-term blood glucose level. The studied groups, control and diabetic patients, were well matched with regard to age, % of smokers, % drinkers and % hypertensive and physical activity. The relationships between glucose, fructosamine and % HbA1c levels were investigated. In addition, the relationships between glucose, fructosamine, HbA1c levels and apolipoproteins from the lipoproteins were also studied. A significant correlation (p < 0.05) between glucose/fructosamine, glucose/HbA1c and fructosamine/HbA1c was found in both groups of diabetic patients with HbA1c lower than 7% and higher than 7% respectively. However HbA1c levels were positive and significantly (p < 0.05) correlated with the Apo-B and Apo-E and negative but significantly correlated (p < 0.05) with Apo-CII and Apo-CIII from VLDL particle in both groups of diabetic patients.