Pharmacokinetics of cadmium-109 in blood and brain structures of the rat

Abstract

Pharmacokinetics of cadmium chloride (109Cd) in blood and cerebral structures in male Wistar rats is studied.Blood kinetics is obtained after intravenous administration of 20 microCi 109Cd; the element is distributed according to an open bicompartimental model with a high alpha deposition constant.The half-life of the alpha-phase is 0.043 hours and the half-life of the beta-phase is 5.54 hours.The kinetics of 109Cd in cerebral structures is calculated after injection of a total amount of 1 microCi in both lateral ventricles.Cadmium radionuclide in cerebral structures of the rat is rapidly fixed from the cerebral fluid, but released slowly.The structure of major accumulation is striatum and that of minor accumulation is cerebellum.