Splanchnic and systemic hemodynamic alterations in chronic, progressive portal hypertensive rats

Abstract

Systemic and splanchnic hemodynamics were studied by using the radioactive microsphere technique, in rats in which a chronic and progressive portal or intrahepatic hypertension was produced by the placement of a nonconstricting, well fitted ligature around the portal or suprahepatic vein when the rat weighted about 100 g.The hemodynamic measurements were performed 80-090 days after ligature placement.Suprahepatic ligated rats presented portal and intrahepatic hypertension, but nonportal-systemic shunts (PSS).The only hemodynamic disturbance observed was a decrease in renal blood flow.Portal ligated rats showed a wide range of PSS and were divided in two subgroups.The subgroups with high PSS rate (greater than 10%) showed increased cardiac output and plasma renin content, as well as decreased splanchnic blood flow, portal venous inflow, hepatic blood flow and renal blood flow.Low portal-systemic shunts subgroups showed decreased cardiac output while its distribution was similar to the control rats.There was no correlation between portal pressure and shunt rate.Low shunt groups, furthermore, showed increased levels of plasma renin concentration.