Aldosterone regulation in anephric patients

L.M. Ruilope
S. Casado
L. Hernando
R. García-Robles
E. Mancheño
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Abstract

The response of plasma aldosterone to hemodialysis, 3 h orthostatism, K-loading and angiotensin II and ACTH infusions has been studied. Hemodialysis, orthostatism and angiotensin II infusion do not modify aldosterone levels. By the contrary ACTH and potassium originate a significant increase in plasma aldosterone. They seem to be the main aldosterone secretion regulators in the absence of renin production.

Keywords:
Renal Dialysis, Adrenocorticotropic Hormone/pharmacology, Aldosterone/blood/metabolism, Angiotensin II/pharmacology, Humans, Kidney/physiology/surgery, Nephrectomy, Posture, Potassium/pharmacology, Secretory Rate/drug effects

Authors

L.M. Ruilope
S. Casado
L. Hernando
R. García-Robles
E. Mancheño


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