Inhibiting effect of (sarcosine-1-isoleucine-8)-angiotensin II in anesthesized rats

J.M. Gandarias; L. Casis; E. Casis; R. Gómez; C. Iribar

J.M. Gandarias

L. Casis

E. Casis

R. Gómez

C. Iribar

PDF (Spanish) (

22)

Published: 1987-03-01

Keywords:

Anesthesia, Angiotensin II/analogs and derivatives/antagonists and inhibitors/pharmacology, Animals, Binding, Blood Pressure/drug effects, Competitive, Inbred Strains, Male, Rats

How to Cite

Inhibiting effect of (sarcosine-1-isoleucine-8)-angiotensin II in anesthesized rats. (1987). Revista Española De Fisiología, 43(1), 77-80. https://revistas.unav.edu/index.php/ref/article/view/46835

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Abstract

The peptidic sequence (Sarcosine-1-Isoleucine-8)-Angiotensin II has been demonstrated to be an in vitro specific and competitive antagonist of the Angiotensin II action.The present results show it to be a competitive antagonist also in vivo since pA2 values are similar, always reaches a 100% response on increasing the Angiotensin II dose, and when relating log (DR-1) and log dose of agonist, the slope is very near to one (0.925).

Keywords:

Anesthesia, Angiotensin II/analogs and derivatives/antagonists and inhibitors/pharmacology, Animals, Binding, Blood Pressure/drug effects, Competitive, Inbred Strains, Male, Rats