Inhibiting effect of (sarcosine-1-isoleucine-8)-angiotensin II in anesthesized rats

J.M. Gandarias
L. Casis
E. Casis
R. Gómez
C. Iribar
65

Abstract

The peptidic sequence (Sarcosine-1-Isoleucine-8)-Angiotensin II has been demonstrated to be an in vitro specific and competitive antagonist of the Angiotensin II action.The present results show it to be a competitive antagonist also in vivo since pA2 values are similar, always reaches a 100% response on increasing the Angiotensin II dose, and when relating log (DR-1) and log dose of agonist, the slope is very near to one (0.925).

Keywords:
Anesthesia, Angiotensin II/analogs and derivatives/antagonists and inhibitors/pharmacology, Animals, Binding, Blood Pressure/drug effects, Competitive, Inbred Strains, Male, Rats

Authors

J.M. Gandarias
L. Casis
E. Casis
R. Gómez
C. Iribar


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