Effect of various adenine derivatives on gastric acid secretion in the isolated rat stomach

Abstract

The adenine derivatives adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate (AMP) and adenosine (AD), in concentrations of 10(-03)M and 10(-4)M caused significant and dose-related modifications in the basal acid secretion from isolated whole rat stomach.The first three purine derivatives, ATP, ADP and AMP significantly increased the spontaneous acid secretion.On the other hand, AD caused a significant reduction in the basal acid secretion.When ATP, ADP, AMP and AD were assayed in the presence of the adrenergic and cholinergic blocking agents, ergotamine, 10(-06)M, propranolol, 5 X 10(-7)M and atropine, 10(-06)M, all these purine derivatives, including AD, caused a significant increase in the basal acid secretion.