Effects of various physiologic adenine derivatives on the secretion of acid in isolated gastric glands in rabbits

Abstract

The physiological adenine derivatives, adenosine (ADO), adenosine 5'-monophosphate (AMP), adenosine 5'-diphosphate (ADP) and adenosine 5'-triphosphate (ATP) at concentrations ranging from 10 microM to 1 mM caused concentration-related modifications on gastric H+ secretion, as measured by the aminopyrine accumulation method, in resting and histamine-stimulated rabbit gastric glands.In resting glands, ADO caused significant concentration-related increases of the basal H+ secretion, whereas no changes were obtained in response to the other purines tested.In histamine-stimulated glands, ADO and AMP caused concentration-related potentiation of the histamine-raised H+ secretory rate, while ATP and ADP induced graded inhibition.The results suggest the involvement of purinergic mechanisms in the physiological regulation of the gastric acid secretory process.