A comparative study between Fc receptor bearing cells and antibody dependent cell cytotoxicity in cancer patients

Abstract

The capacity of 14 cancer patients lymphoid cells to destroy antibody-coated target cells (antibody-dependent cell cytotoxicity ADCC), and to form rosettes with immunoglobulin-coated erythrocytes (EA) was compared.The lymphocyte functions were investigated immediately prior to chemo-immunotherapy.Our observations show a correlation between the percentage of EA-rosette forming cells and ADCC activity of cancer patients and controls.However, the regressive lines were different in both groups.Interestingly, cancer patients with a lower.EA rosette forming cells than controls, showed higher cytotoxic activity.