A comparative study between Fc receptor bearing cells and antibody dependent cell cytotoxicity in cancer patients

F. Gutiérrez
E. Sánchez-Cantalejo
E. Garcia-Olivares
F. Garrido
C. Osorio
48

Abstract

The capacity of 14 cancer patients lymphoid cells to destroy antibody-coated target cells (antibody-dependent cell cytotoxicity ADCC), and to form rosettes with immunoglobulin-coated erythrocytes (EA) was compared.The lymphocyte functions were investigated immediately prior to chemo-immunotherapy.Our observations show a correlation between the percentage of EA-rosette forming cells and ADCC activity of cancer patients and controls.However, the regressive lines were different in both groups.Interestingly, cancer patients with a lower.EA rosette forming cells than controls, showed higher cytotoxic activity.

Keywords:
Antibody-Dependent Cell Cytotoxicity, Adult, Aged, Fc/immunology, Humans, Lymphocytes/immunology, Middle Aged, Neoplasms/immunology, Receptors, Rosette Formation

Authors

F. Gutiérrez
E. Sánchez-Cantalejo
E. Garcia-Olivares
F. Garrido
C. Osorio


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