Levels of manganese and iron in the brain of normal and manganese-poisoned rats

Abstract

Forty rats were poisoned by manganese inhalation and were sacrificed after six and nine months.Tissue concentrations (in mg/g dry weight) were measured in brain, cerebellum and stem-brain of the experimental animals and the twenty control rats, for atomic absorption spectometry.The increase in tissue manganese concentrations were very pronounced in cerebellum, and minor in brain and stem-brain.The tissue iron concentrations undergo a light increase in cerebellum and stem-brain.