Effect of phosphoenolpyruvate on liver mitochondrial calcium retention from fed and fasted rats

M. Lucas
C. Osuna
R. Goberna
39

Abstract

Rat liver mitochondria from fed and 4-day-fasted rats are able to accumulate calcium supported by ATP (energy-driven calcium uptake) or by succinate (respiration-driven calcium uptake).Phosphoenolpyruvate decreases the amount of calcium accumulated in both ways, whether the rats were fasted or fed ad libitum.Phosphoenolpyruvate induces a net calcium efflux from mitochondria.The effect of phosphoenolpyruvate is partially reversed by ADP.Phosphoenolpyruvate is also able to inhibit the ATP-driven calcium accumulation in the absence of exogenously added respiratory substrates.

Keywords:
Fasting, Active, Adenosine Diphosphate/metabolism, Adenosine Triphosphate/metabolism, Animals, Biological Transport, Calcium/metabolism, Female, Kinetics, Liver/drug effects/metabolism, Mitochondria, Phosphoenolpyruvate/pharmacology, Rats, Succinates/metabolism

Authors

M. Lucas
C. Osuna
R. Goberna


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