GABA uptake by human blood platelets: effects of lithium and rubidium chlorides

M.J. Oset-Gasque; M.P. González-González

M.J. Oset-Gasque

M.P. González-González

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Published: 1983-09-01

Keywords:

Active/drug effects, Adult, Biological Transport, Blood Platelets/drug effects/metabolism, Chlorides/pharmacology, Diffusion, Female, Humans, Kinetics, Lithium Chloride, Lithium/pharmacology, Male, Middle Aged, Rubidium/pharmacology, Serotonin/metabolism, gamma-Aminobutyric Acid/blood/metabolism

How to Cite

GABA uptake by human blood platelets: effects of lithium and rubidium chlorides. (1983). Revista Española De Fisiología, 39(3), 237-242. https://revistas.unav.edu/index.php/ref/article/view/47129

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Abstract

The methodologic and kinetic characteristics of GABA uptake by platelets were determined in blood platelets of volunteer donors.Extrapolation of a reciprocal plot indicate two uptake systems: a high affinity and a passive diffusion mechanism.When LiCl and RbCl were added in vitro, they had no effect on platelet GABA uptake.Our data suggest that platelet GABA and 5-HT uptake are carried out by different systems.

Keywords:

Active/drug effects, Adult, Biological Transport, Blood Platelets/drug effects/metabolism, Chlorides/pharmacology, Diffusion, Female, Humans, Kinetics, Lithium Chloride, Lithium/pharmacology, Male, Middle Aged, Rubidium/pharmacology, Serotonin/metabolism, gamma-Aminobutyric Acid/blood/metabolism