GABA binding in human blood platelets: in vitro effects of lithium and rubidium chlorides

M.J. Oset-Gasque; M.P. González-González

M.J. Oset-Gasque

M.P. González-González

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Published: 1983-09-01

Keywords:

Adult, Binding Sites, Blood Platelets/drug effects, Cell Surface/drug effects/metabolism, Chlorides/pharmacology, Female, GABA-A, Humans, Kinetics, Lithium Chloride, Lithium/pharmacology, Male, Middle Aged, Receptors, Rubidium/pharmacology, Serotonin/metabolism, gamma-Aminobutyric Acid/blood/metabolism

How to Cite

GABA binding in human blood platelets: in vitro effects of lithium and rubidium chlorides. (1983). Revista Española De Fisiología, 39(3), 243-248. https://revistas.unav.edu/index.php/ref/article/view/47130

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Abstract

Methodologic and kinetic properties of gamma-aminobutyric acid (GABA) binding were studied in platelet materials of different nature.Platelet GABA binding was saturable and specific.LiCl and RbCl added in vitro at concentration of 0.01 mM increased significantly platelet GABA binding.This activator effect, and its kinetic characteristics were different from those obtained for GABA uptake and 5-hydroxytryptamine (5-HT) binding, which suggest that the three processes are different in platelets.

Keywords:

Adult, Binding Sites, Blood Platelets/drug effects, Cell Surface/drug effects/metabolism, Chlorides/pharmacology, Female, GABA-A, Humans, Kinetics, Lithium Chloride, Lithium/pharmacology, Male, Middle Aged, Receptors, Rubidium/pharmacology, Serotonin/metabolism, gamma-Aminobutyric Acid/blood/metabolism