Ca2+-dependent K+ transport in lymphocytes

A. Sánchez
M. Valdeolmillos
J. García-Sancho
B. Herreros
52

Abstract

The treatment of rat thymocytes with A23187 + Ca2+, ascorbate-phenazine methosulphate or propranolol induced quinine-sensitive fluxes of K+ (Rb+) suggesting the presence in the cell membrane of Ca2+-dependent K+ channels.Concanavalin A induced K+ channel activation only at very high doses (13 micrograms/ml).Neither quinine nor the increase of the K+ concentration in the medium to 30 mM prevented the stimulation of amino acid transport induced by concanavalin A, suggesting that the Ca2+-dependent K+ channel is not involved in the early phenomena of lymphocyte activation.

Keywords:
Animals, Biological Transport, Calcimycin/pharmacology, Calcium/pharmacology, Humans, Potassium/metabolism, Propranolol/pharmacology, Radioisotopes/metabolism, Rats, Rubidium/metabolism, T-Lymphocytes/metabolism

Authors

A. Sánchez
M. Valdeolmillos
J. García-Sancho
B. Herreros


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