T-lymphocyte behaviour modification in vitro by cancer patient sera

Abstract

Cell mediated immune response blocking factor(s) in the serum of colon adenocarcinoma patients inhibit blast transformation of lymphocytes from normal individuals.The blocking capacity of the sera has been shown to correlate with the infiltration of the tumor.This correlation suggests that these phenomena may be mediated by identical serum factors and through a common cell receptor present in the lymphocytes of normal individuals.