Effects of bilateral nephroadrenectomy on the composition of perilymphatic fluid in the rat

Abstract

The examination of osmolality and ionic composition of plasma and perilymphatic liquid of nephroadrenectomized rats was performed by systematic methods.Significant increases in osmolality, Na and K concentrations were found in perilymph of nephroadrenectomized animals.The functional importance of these findings is evaluated, and the influence of blood labyrinth barrier and osmotic mechanisms on these results is discussed.Simultaneously, the possibility that similar mechanisms might be involved in the pathogenesis of Meniere's disease is pointed out.A possible route on pathogenical and clinical studies in labyrinth pathology is enhanced.