Effect of cycloheximide on liver carcinogenis induced by diethylnitrosamine

Abstract

This work is related to the protein syntliesis inhibition realized by Cycloheximide on the experimental liver carcinogenesis by diethylnitrosamine.

The animáis were divided in 3 groups; the first one received only cycloheximide; a second one was treated with diethylnitrosamine and the last one received simul- taneously cycloheximide and diethylnitrosamine.

Studies with light microscope don't show important changes in the first of them. The second group as well as the third, present a sequence of alterations that in the first stage ruled over the toxic effect and afterwards coexist with the development of morphological carcinogenesis precursors: the hyperbasophilic foci and finally growing hepatomas.

The microscopic electronic observations reveal differences in the rough endoplasmic reticulum and in the nucleolar structure in the group treated simultaneously with both substances, comparing with the one which receive exclusively diethylnitrosamine, while in the first group the changes are few and resemble those of the third one but on the first phase.

It is discussed why the carcinogenesis process is not altered and the possible mechanisms involved.