Evaluation of macrocytosis production in relation to the dosage and form of administration of erythropoietin

Abstract

The dose-response relationship between erythropoietin and the production of macrocytes depends in part, on the interval over which a given amount of erythropoietin is administered. This reflects the rate of metabolism of this substance. With our data we have demonstrated that macrocytosis which results from skipped terminal divisions is greatest when erithropoietin is given as a continuous infusión.