Patterns of plasma proteins and glycoproteins in diabetic dogs

Abstract

This work puts forward data obtained from 27 pancreatectomized dogs which lived for a duration of greater than a month, during which period a study was made on the relative com- pensation by exogenous insulin; and on tyrosine the supression of this substitutíve treatment during a determined lenght of time. The study of the seromucoid fractions of tyrosine, hexoses (galactose, mannose), glucosamine and sialic acid of these animáis, with simultaneous determi- nations of the total proteins and its fractions; and of the glucemic levels were performed. The results showed an increase in all the seromucoid fractions, with modérate level in insulin treated dogs. The plasma proteins followed a totally inverse pattem with a tendency to increase discretely on controlling the dogs with insulin. The protein fractions showed a decrease in albumin and an increase in alpha globulins, the changes in the rest of the fractions registered were of minor importance. The glucemic levels displayed a great variability, especially in its day to day levels.