In vivo action of phytohemagglutinin on the erythropoiesis of mice

Abstract

In the 48-72 hour period that follows phytohemaglutinin injection to fasted mice a series of changes in the spleen occur similar to those found in normal mice after phytohemaglutinin. In the same period the splenic erythropoietic response to erythro­ poietin stimulation becomes greatly increased. This increased response to erythropoietin is accompanied by a greater concentration of Stem Cells in the spleen. The possibility that the transformed lynphocytes may act as erythropoietic progenitors under the influence of EP an discussed.