Functional study of gastric homotransplants

Abstract

One study in dogs with Pavlov’s Pouch and with a gastric allogeneic homograft, the secretion of acid, pepsin and ions are induced by distinct stimuli.

The acidic secretion of trasplanted stomachs in response to diverse stimuli is equal to that obtained by other authors with vagectomized stomach preparations; indicating unimpaired parietal cell function.

On the other hand, the peptic cells do not secrete, no matter what stimulus is employed for this purpose.

This dissociation of cellular responses demonstrates the possibility of mutually inde­ pendent mechanisms of secretion.

It appears that the secretion of sodium (Na+) and potassium (K+), at least in part, depends upon the specific stimulus utilized. In the transplant, histamine is more con­ ducive to Na+ secretion; meat exercises greater effect on K+ secretion.

Histologic alterations are observed in the chief cells; while the parietal cells appear unchanged.