Effect of phenformin on gluconeogenesis in perfused rat liver

Abstract
The effect of phenformin on gluconeogenesis from several gluconeogenic substrates in perfused rat liver is reported.
1 mM phenformin inhibited gluconeogenesis from L-lactate and fructose (10 mM). A lag period (20-40 min.) was required before phenformin showed a clear inhibitory effect. The inhibition is more pronounced from 10 mM glycerol and takes place as soon as phenformin is added to the perfusion medium.
Theese results suggest a wide and indirect effect of phenformin on gluconeogenesis, probably related to its inhibitory effect on the electron transport chain.
Keywords:
Animals, Female, Fructose/metabolism, Gluconeogenesis/drug effects, In Vitro Techniques, Inbred Strains, Lactose/metabolism, Liver/drug effects/metabolism, Perfusion, Phenformin/pharmacology, Rats
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