Effect of phenformin on gluconeogenesis in perfused rat liver

J.M. Medina; F. Sánchez-Medina; F. Mayor

J.M. Medina

F. Sánchez-Medina

F. Mayor

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Published: 1971-09-01

Keywords:

Animals, Female, Fructose/metabolism, Gluconeogenesis/drug effects, In Vitro Techniques, Inbred Strains, Lactose/metabolism, Liver/drug effects/metabolism, Perfusion, Phenformin/pharmacology, Rats

How to Cite

Effect of phenformin on gluconeogenesis in perfused rat liver. (1971). Revista Española De Fisiología, 27(3), 253-256. https://revistas.unav.edu/index.php/ref/article/view/49276

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Abstract

The effect of phenformin on gluconeogenesis from several gluconeogenic substrates in perfused rat liver is reported.

1 mM phenformin inhibited gluconeogenesis from L-lactate and fructose (10 mM). A lag period (20-40 min.) was required before phenformin showed a clear inhibitory effect. The inhibition is more pronounced from 10 mM glycerol and takes place as soon as phenformin is added to the perfusion medium.

Theese results suggest a wide and indirect effect of phenformin on gluconeogenesis, probably related to its inhibitory effect on the electron transport chain.

Keywords:

Animals, Female, Fructose/metabolism, Gluconeogenesis/drug effects, In Vitro Techniques, Inbred Strains, Lactose/metabolism, Liver/drug effects/metabolism, Perfusion, Phenformin/pharmacology, Rats