Effect of cobalt chloride intoxication on seric lipids level and other parameter

Abstract

This work studies the lipidie metabolism after having destroyed with cobalt chloride (single dose of 50 mg/kg of body weight by intramuscular route) the alpha cells of páncreas which produce glucagon.
Lots of ten dogs have been utilized. Determinalions of triglycerides. glycerol and fatty acids as well as lipase and glucose have been carried out in serum. The trial lasted for 30 days and the analytical tests were done on the 3rd, 7*h, 15th and 30th day.

There was a mobilization of lipids with a significant increase of lipids. During the 30 days trial there was an increase of triglycerides together with an increase of fatty acids of free and total glycerol. There were no great variations of the glucose; it in­ creases slightly on the 7th day but recovers its normal valué by the end of the trial. There was a slight decrease of the enzyme lipase.