Effects of tryptophan metabolites on glucose uptake and carbon dioxide output by the rat adipose tissue in vitro

Abstract

Two índole acids (2 X 10-3 M) inhibited, significantly, the CO. output and the glu­ cose uptake by rat adipose tissue incubated with Krebs-Ringer bicarbonate (pH 7.4) glucose plus insulin. The effects of indolacetic were greater than that of indolpyruvic. These compounds did not modify the respiratory rate of the adipose tissue incubated in Krebs-Ringer phosphate. These results are against the possibility (at least for adipose tissue) that the tryptophan metabolites prevents epinephrine-induccd hyperglycemia bx enhancing glucose uptake from the blood into pcripheral tissues.