Prevention of some Ethionine-induced liver alterations in rats by silmarine
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30)
Published:
1973-09-01
Keywords:
Alcohols/therapeutic use, Animals, Chemical and Drug Induced Liver Injury/drug therapy/metabolism/pathology/prevention and control, Ethionine/poisoning, Fatty Liver/chemically induced/pathology/prevention and control, Female, Flavonoids/therapeutic use, In Vitro Techniques, Injections, Intraperitoneal, Lipid Metabolism, Liver Glycogen/metabolism, Liver/drug effects/metabolism/pathology, Oxygen Consumption/drug effects, Rats
How to Cite
Prevention of some Ethionine-induced liver alterations in rats by silmarine. (1973). Revista Española De Fisiología, 29(3), 227-232. https://revistas.unav.edu/index.php/ref/article/view/49374
70
Abstract
The respiratory activity of liver slices from female rats treated with D-L Ethionine is inhibited. Also, there are histological (fatty metamorphosis) and biochemical changes (total lipids accumulation, loss of glycogen).
Silimarine seems to repair, in some way, the liver damages produced by ethionine. because liver slices from rats treated with ethionine and silimarine almost do not have biochemical changes and the metamorphosis does not appear.
Keywords:
Alcohols/therapeutic use, Animals, Chemical and Drug Induced Liver Injury/drug therapy/metabolism/pathology/prevention and control, Ethionine/poisoning, Fatty Liver/chemically induced/pathology/prevention and control, Female, Flavonoids/therapeutic use, In Vitro Techniques, Injections, Intraperitoneal, Lipid Metabolism, Liver Glycogen/metabolism, Liver/drug effects/metabolism/pathology, Oxygen Consumption/drug effects, Rats
Authors
F. García-Pravia
M. Sopena-Dasí
J.R. de Prada
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