Action of the sulfonylureas tolbutamide and glypentide on the lacticdehydrogenase plasma levels

Abstract

Action of the Sulfonylureas Tolbuta- mide and Glypentide on the Lacticdehydrogenase Plasma Levels. Rev. esp. Fisiol., 30, 91-96. 1974.

The effect of tolbutamide and glypentide (a new oral hypoglycemic agent) on the lactate dehydrogenase (L.D.H.) plasma levels of rabbits and rats has been studied.

The administration of single oral doses of these drugs (150 mg/'kg tolbutamide and 5 mg/kg glypentide in rabbits; 150 mg/ kg tolbutamide and 25 mg/kg glypentide in rats), produces a similar blood sugar decrease in both species. However L.D.H. plasma levels of animáis treated with tolbutamide increase considerably.

Contrarily, glypentide does not induce any significative increase of enzymatic acti- vity in rabbits plasma. In rats plasma was observed a significative increase of 38 %

only five hours after administration.
These results are in good agreement with those described by other authors about

the extrapancreatic actions of tolbutamide and make us to think in a greater pancreatic specificity of glypentide.