Lack of correlation between antiinflammatory activity and inhibition of 3',5'-Cyclic AMP phosphodiesterase activity in a series of antiinflammatory agents

Abstract

The effect of several non steroid antiinflammatory agents on beef heart phospho­ diesterase has been studied. A comparison of this effect with the in vivo antiinflammatory activity determined in rat (Winter’s method) and with the recommended clinical daily dose in rheumatoid arthritis, reveals a lack of correlation. The possibility that cyclic AMP plays an important role in the inflammatory response cannot be completely ruled out, but it can be safely concluded fron the present study that the measurement of the inhibition of beef heart phosphodiesterase by potential antiinflammatory agents cannot be used as a test to predict their antiinflammatory activity.