Influence of sodium palmitate in the solubilization of cholesterol in an in vitro model of bile

Abstract

Influence of Sodium Palmitate in the Solubiliza­ tion of Cholesterol in an in vitro Model of Bile. Rev. esp. Fisiol., 30, 119-126. 1974. The cholesterol solubilizing power of sodium palmitate in aqueous solutions of sodium taurodeoxycholate and lecithin in models in vitro, has been explored. From

the results, it appears that sodium palmitate increase moderately the cholesterol solu­ bilizing power of the systems and that the relationship between solubilized cholesterol and palmitate concentration is linear, the slope of the straight lines depending upon the concentration of the lecithin present. The regression slope has been quantified and also the equation which relates the increases of cholesterol due to the concentra­ tion of the soap, and the concentrations of it and of the lecithin.

It is suggested that the discrepancies between «supersaturation» of cholesterol, according to the models cited in the literature, and the non occurrence of gallstones may be attributable to not taking into account the sodium palmitate concentration in the bile samples under study.