Effect of methionine sulfone on the growth of Citrobacter intermedius C3

A. Juárez
R. Parés
J. Vives
54

Abstract

Specific activity of glutamate dehydrogenase (GD) and glutamate synthase (GtS) has been determined in the wild strain C3 and on a non excreting pro- mutant strain. Methionine sulfone shows inhibitory effects on their growth. The addition of alpha-ketoglutarate to the medium prevents the inhibitory effect and increases the GtS specific activity in both strains. The physiological effect of methionine sulfone and its suppression by alpha-ketoglutarate is discussed.

Keywords:
Animals, Citrobacter/growth and development, Enterobacteriaceae/growth and development, Glutamate Dehydrogenase/antagonists and inhibitors/metabolism, Glutamate-Ammonia Ligase/antagonists and inhibitors/metabolism, Methionine/pharmacology

Authors

A. Juárez
R. Parés
J. Vives


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