Kinetics of IgM and IgG responses in neonatally thymectomized Swiss mice under persistent immunization with sheep red blood cells

Abstract

The kinetics of IgM and IgG responses (direct and indirect PCF) in the Swiss mice, neonatally thymectomized, injected three times a week with 5 X 10(8) sheep erythrocytes at the age of two months, were exactly the same as the controls from the same litters.The thymectomized animals showed a statistically significant decrease in both responses (18.6 and 30.2%, respectively).The kinetics of the switch from IgM to IgG and of the latter response inhibition, is the same in both the control and the thymectomized animals.