Effect of intracerebroventricular injection of 6-hydroxydopamine and 5,6-dyhydroxytryptamine on the phasic secretion of luteinizing hormone

Abstract
In ovariectomized rats carrying an estradiol sylastic implant the effect of the intraventricular administration of the serotonin neurotoxin 5,6-dihydroxytryptamine and of the norepinephrine neurotoxin 6-hydroxydopamine on the circadian secretion of the luteinizing hormone (LH) was studied. The decrease of 5-HT after injection of 5,6-dihydroxytryptamine reduced the a.m. and p.m. values and suppressed the phasic rhythm of LH. The diminution of noradrenaline after administration of 6-hydroxydopamine increased the a.m. and did not alter the p.m. values, resulting in a partial abolition of the rhythm.
Keywords:
Animals, Brain Chemistry, Castration, Chemical, Circadian Rhythm/drug effects, Dihydroxytryptamines/pharmacology, Estradiol/pharmacology, Female, Hydroxydopamines/pharmacology, Luteinizing Hormone/metabolism, Norepinephrine/analysis/metabolism, Ovary/physiology/surgery, Rats, Secretory Rate/drug effects, Serotonin/analysis/metabolism, Stimulation
Authors
Issue
Section
Articles