Effect of intracerebroventricular injection of 6-hydroxydopamine and 5,6-dyhydroxytryptamine on the phasic secretion of luteinizing hormone

P. Montilla
M. Muñoz
J.L. Palacios
56

Abstract

In ovariectomized rats carrying an estradiol sylastic implant the effect of the intraventricular administration of the serotonin neurotoxin 5,6-dihydroxytryptamine and of the norepinephrine neurotoxin 6-hydroxydopamine on the circadian secretion of the luteinizing hormone (LH) was studied. The decrease of 5-HT after injection of 5,6-dihydroxytryptamine reduced the a.m. and p.m. values and suppressed the phasic rhythm of LH. The diminution of noradrenaline after administration of 6-hydroxydopamine increased the a.m. and did not alter the p.m. values, resulting in a partial abolition of the rhythm.

Keywords:
Animals, Brain Chemistry, Castration, Chemical, Circadian Rhythm/drug effects, Dihydroxytryptamines/pharmacology, Estradiol/pharmacology, Female, Hydroxydopamines/pharmacology, Luteinizing Hormone/metabolism, Norepinephrine/analysis/metabolism, Ovary/physiology/surgery, Rats, Secretory Rate/drug effects, Serotonin/analysis/metabolism, Stimulation

Authors

P. Montilla
M. Muñoz
J.L. Palacios


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