Action of water-soluble cortical preparations (deoxycorticosterone acetate) on prolonged insulin coma

Abstract

The course of prolonged insulinic coma has been studied in two series of dogs: some were given glucose only, in a 40 % solution, while others were injected besides intervenously, %ith highly concentrated cortical hydrosoluble preparations.

It was observed that the animals of the former group all died with symptoms of a marked suprarenal deficit, whilst those that had received hydrosoluble cortical preparations all carne out of coma, the posterior course being completely normal.

Considerations were made on the part played by the suprarenal cortex in the course of prolonged insulinic coma.