Hypoglycemic action of a new sulfonamide, in different doses, in normal dogs

Abstract

The hypoglycemic properties of the N-p-isopropoxy-benzoyl-p-toluenesulfonamide are studied. We have investigated, not only the duration of the glycemic drop brought on by a determined dose, but also the relation existing between the dose administered and the persistence of a low glycemic level.

We have used doses of 5, 10, 15, 100 and 200 mg. per Kg of weight, and have determined the glycemic level at 4, 6 and 8 hours, which in elevated doses has been extended to 24 hours [this determination was justified by the results previously obtained with 4-isopropoxy-benzoil -sulfanilamide (7)].

The dose of 5 mg per Kg produces a slight gycemic drop of about 10 %. With the 10 mg dose one obtains an average drop of about 14 % at 4 hours. which tends to decome normal at 6 and 8 hours. The dose of 15 mg provokes, at 4 hours, a hypoglycemia of minus 27 %, which practically disappears at 6 and 8 hours.

The principal result obtained from the administration of larger doses has been that low glycemic level remains unchanged for several hours. Thus, with 100 mg, it remains, from the fourth to the eighth hour, at between minus 15 % and minus 22 %. With 200 mg, the hypoglycemia varies between minus 31 % and minus 34 % at the hours quoted, and at 24 hours it still maintains a level of minus 14 %.

If we take into account the proceding results, and those obtained with the use of chloroprapamide, we must suppose that the substitution, in the molecule under consideration, of the methylic group in para position by a Cl, will have as a consequance a further prolongation of the hypoglycemic effect.