Effects of different subchronic treatments with lindane on some brush border enzymes in rat jejunum
Article Sidebar
20)How to Cite
53
Abstract
Subchronic lindane (y-HCH) intoxication by oral or s.c. injection over 7 and 15 days, induced a significant inhibition in rat jejunum maltase activity when the pesticide was administered at doses of 20 mg/kg b. wt. However, maltase levels remained unaffected in those animals injected with 10 mg/kg of lindane. A longer period of s.c. lindane exposure (30 days) at doses of 10 mg/kg induced a significant decrease in maltase activity, although the injection of 20 mg/kg over the same period did not alter this enzyme activity. When this lindane dose was s.c. injected over 20 days a significant inhibition of maltase activity was observed. However no changes in this enzyme were found in rats injected over 25 days. This fact seems to suggest that between 20-25 days of pesticide exposure the organism develops possible regulatory mechanisms to counteract the alterations induced by this dose of lindane on maltase activity. Lactase and alkaline phosphatase activities were not altered by lindane action in different treatments performed. Sucrase activity was only altered in oral injected rats at doses of 20 mg/kg over 15 days. In conclusion, maltase activity seems to be more sensitive to lindane action than other brush border enzymatic proteins; lindane effects on this enzyme depend on the injected dose and the pesticide administration period duration.
Authors
References
Antunes-Madeira, M. C. and Madeira V. M. C. (1985): Biochim. Biophys. Acta, 820, 165-172 . https://doi.org/10.1016/0005-2736(85)90109-9
Brasitus, T. A., Schachter, D. and Mamouneas, T. G. (1979): Biochemistry, 18, 4136-4144 . https://doi.org/10.1021/bi00586a013
Brasitus, T. A. and Schachter, D. (1980): Biochemistry,19, 2763-2769 . https://doi.org/10.1021/bi00553a035
Brasitus, T. A., Dahiya, R., Dudeja, P. K. and Bissonnette, B. M. (1988): J. Biol. Chem., 25, 8592-8597 . https://doi.org/10.1016/S0021-9258(18)68345-0
Camon, L., Sola, C., Martinez, E., Sanfcliu, C and Rodriguez-Farre, E. (1988): Toxicology, 49, 381-387 . https://doi.org/10.1016/0300-483X(88)90022-4
Camon, L., Martinez, E., Artigas, F., Sola, C and Rodriguez-Farre, E. (1988): Toxicology, 49, 389-394 . https://doi.org/10.1016/0300-483X(88)90023-6
Carrero, L, Prieto, J. C., Recio, M. N., Del Hoyo, N. and Perez-Albarsanz, M.A. (1993): Pestic. Biochem. Physiol., 47, 69-78 . https://doi.org/10.1006/pest.1993.1064
Cooper, R. L., Chadwick, R. W., Rehnbcrg, G. L., Goldman, J. M., Booth, K. C., Hein, J. F. and McElroy, W. K. (1989): Toxicol. Appl. Pharmacol., 99, 384-394 . https://doi.org/10.1016/0041-008X(89)90148-8
Dahlqvist, A. (1964): Anal. Biochem., 7, 18-25 . https://doi.org/10.1016/0003-2697(64)90115-0
Dikshith, T. S., Raizada, R. B., Srivastava, M. K. (1991): J. Toxicol. Environ. Health, 34,495-507 . https://doi.org/10.1080/15287399109531585
Drummond, L., Gillanders, E. M. and Wilson, H. K. (1988): Br.J. Ind. Med., 45, 493-497 . https://doi.org/10.1136/oem.45.7.493
Dudeja, P. K. and Mahmood, A. (1982): Arch Toxicol., 49, 131-138 . https://doi.org/10.1007/BF00332360
Gutierrcz-Ocana, M. T., Lopez-Aparicio, P., Perez-Albarsanz, M. A. and Recio, M. N. (1989): Biochim. Biophys. Acta, 1003, 67-71 . https://doi.org/10.1016/0005-2760(89)90100-8
Guticrrez-Ocana, M. T., Senar, S., Perez-Albarsanz, M. A. and Recio, M. N. (1992): Biosci. Rep., 12, 303-311 . https://doi.org/10.1007/BF01122802
Jones, O. T. and Lee, A. G. (1985): Biochim Biophys. Acta, 812, 731-739 . https://doi.org/10.1016/0005-2736(85)90267-6
Lowry, O. FL, Roscbrough, N. J., Farr, A. L and Randall, R. J. (1951): J. Biol. Chem., 193, 265-275 . https://doi.org/10.1016/S0021-9258(19)52451-6
Llorens, J., Tusell, J. M., Sunol, C. and Rodriguez
Madara, J. L. and Trier, J. S. (1987): In "Physiology of the Gastrointestinal Tract", (L. R.Johnson, ed.). Raven Press, New York, vol. 2, pp. 1209-1250 .
Marquis, J. K. (1989): In "A guide to General Toxicology", (Marquis, Hayes eds.). S Karger, Basel, vol 5, pp. 157-178 .
Moody, R. P. (1989): J. Toxicol. Environ .Health, 28,317-326 . https://doi.org/10.1080/15287398909531352
Moreno, M. J., Pellicer, S., Marti, A., Arenas, J C. and Fernandez-Otero, M. P. (1994): Cotnp .Biochem. Physiol., 109 C, 159-166 . https://doi.org/10.1016/0742-8413(94)00050-K
Moreno, M. J., Pellicer, S. and Fernandez-Otero, M. P. (1995): Pestic. Biochem. Physiol., 52,212-221 . https://doi.org/10.1006/pest.1995.1046
Nedkova-Bratanova, N., Ivanov, E., Savov, E., Michailova, Z., Krusteva, A. and Petrova, S (1979): Enzyme, 24, 281-284 https://doi.org/10.1159/000458676
Perez-Albarsanz, M. A., Lopez-Aparicio, P., Senar, S. and Recio, M. N. (1991): Biochim. Biophys Acta, 1066, 124-130 . https://doi.org/10.1016/0005-2736(91)90178-B
Pool-Zobel, B. L., Guigas, C., Klein, R., Neudecker, C. H., Renner, H. W. and Schmezcr, P. (1993): Fd. Chem. Toxic., 31,271-283 . https://doi.org/10.1016/0278-6915(93)90077-C
Ravinder, P., Srinivansan, K. and Radhakrishnamurtv, R. (1989): Indian J. Exp. Biol., 27, 248-251. https://doi.org/10.1016/0041-624X(89)90050-4
Schmitz, R., Preiser, H., Maestracco, D., Ghosh, B. K., Cerda, J. J. and Crane, R. K. (1973): Biochim. Biophys. Acta, 323, 98-112 . https://doi.org/10.1016/0005-2736(73)90434-3
Srinivansan, K., Ramesh, H. P. and Radhakrishnamurty, R. (1988): Bull. Environ. Contain .Toxicol., 41, 531-539 . https://doi.org/10.1007/BF02020997
Srinivansan, K., Mahadevappa, K. L. and Radhakrishnamurty, R. (1991): Bull. Environ. Contain .Toxicol., 47, 623-627 . https://doi.org/10.1007/BF01700955
Sunol, C., Tusell, J. M., Gclpi, E. and Rodn'guez-Farre, E. (1988): Neitropharmacology, 27, 677-681 . https://doi.org/10.1016/0028-3908(88)90075-5
Sunol, C., Tusell, J. M., Gclpi, E. and Rodn'guez-Farre, E. (1989): Toxicol. AppL Pharmacol., 100, 1-8 .
Varela, G., Andujar, M. M. and Navarro, M. P.(1978): In "World review of nutrition and dietetics", (G. H. Bourne ed.). S. Karger, Basel, Vol 30, pp. 148-188 .
Videla, L. A., Simizu, K., Barros, S. B. M. and Junqueira, V. B. C. (1991): Xenobiotica, 21, 1023-1032 . https://doi.org/10.3109/00498259109039542
Wali, R. K., Singh, R. A. J., Dudeja, P. K. and Mahmood, A. (1982): Toxicol. Lett., 12, 7-12 . https://doi.org/10.1016/0378-4274(82)90191-6
Zhu, J., Zulin, F. and Chen, J. (1986): Pestic .Biochem. Physiol., 25, 414-419. https://doi.org/10.1016/0048-3575(86)90016-7
Metrics
|
|