Response of pleural and peritoneal mastocyte populations in the rat to agents with different mechanisms of action

Abstract

Histamine release from rat pleural and peritoneal mast cells not previously purified is presented.Cells are stimulated by different mechanism-acting pharmacologic agents.FNa, theophylline, ruthenium red, chlorpromazine and propranolol are used.Results show that both cell populations are pharmacologically different, with distinct responses in the presence of FNa or chlorpromazine.Chlorpromazine and propranolol are cytolytic agents.