Effect of isoproterenol on histamine release on rat lung mast cells
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20)
Published:
1991-03-01
Keywords:
Adrenergic, Animals, Calcimycin/pharmacology, Calcium/pharmacology, Concanavalin A/pharmacology, Drug Interactions, Histamine Release/drug effects, Isoproterenol/pharmacology, Lung/cytology, Mast Cells/drug effects/metabolism, Rats, Receptors, Sodium Fluoride/pharmacology, beta/drug effects/physiology, p-Methoxy-N-methylphenethylamine/pharmacology, cAMP, Phosphodiesterase
How to Cite
Effect of isoproterenol on histamine release on rat lung mast cells. (1991). Revista Española De Fisiología, 47(1), 13-17. https://revistas.unav.edu/index.php/ref/article/view/46333
54
Abstract
Rat lung mast cells were stimulated with drugs with distinct mechanisms of action, namely concanavalin A, compound 48/80 ionophore A23187, in the presence of the beta adrenergic agonist (-)isoproterenol. Cells show a high response when they are stimulated with FNa-calcium. Isoproterenol does not inhibit histamine release induced by any stimuli, but enhances the response to concanavalin A and compound 48/80. Results point to the lack of beta activity on rat lung mast cells.
Keywords:
Adrenergic, Animals, Calcimycin/pharmacology, Calcium/pharmacology, Concanavalin A/pharmacology, Drug Interactions, Histamine Release/drug effects, Isoproterenol/pharmacology, Lung/cytology, Mast Cells/drug effects/metabolism, Rats, Receptors, Sodium Fluoride/pharmacology, beta/drug effects/physiology, p-Methoxy-N-methylphenethylamine/pharmacology, cAMP, Phosphodiesterase
Authors
M.R. Vieytes
M.C. Louzao
L.F. de la Cruz
L.M. Botana
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