Calcium and renin release: inhibition of low sodium-induced renin secretion by high calcium concentration in rat kidney perfusion

D. Acuña
F. Alba
L. García-Torres
A. Soler
F. Vargas
A.Martín Andrés
C. del Río
C. Osorio
51

Abstract

The effects of changes in calcium on renin secretion have been studied in the isolated perfused rat kidney.Perfusion with free calcium buffer significantly decreases renin secretion as compared with control experiments (Ca++: 2.5 mM/l).Other calcium concentrations (1.25 mM/l) and 5 mM/l) do not affect basal renin secretion.When the renin release is previously increased by low sodium concentration (Na+: 110 mM/l) however, perfusion with high calcium buffer (Ca++: 5 mM/l) significantly inhibits this stimulation.

Keywords:
Animals, Calcium/pharmacology/physiology, Dose-Response Relationship, Drug, Inbred Strains, Juxtaglomerular Apparatus/drug effects, Kidney/drug effects/metabolism, Male, Perfusion, Rats, Renin/metabolism, Sodium/antagonists and inhibitors

Authors

D. Acuña
F. Alba
L. García-Torres
A. Soler
F. Vargas
A.Martín Andrés
C. del Río
C. Osorio


Metrics

Search GoogleScholar



Downloads

Download data is not yet available.

Section

Articles

Most read articles by the same author(s)

1 2 3 4 5 6 > >>