The handling of NaCl load in rats during DOCA-salt and Goldblatt 2 kidney-1 clip hypertension development

Abstract

The handling of an intraperitoneal NaCl load (2% body weight, 0.9% NaCl) administered twice a week during DOCA-salt and Goldblatt 2K-1C hypertension development has been evaluated.An exaggerated natriuresis was observed in DS-hypertensive rats since blood pressure became higher with respect to normal (C), Doca (D) and uninephrectomized-salt (NS) rats that served as controls.However, this phenomenon was not observed in Goldblatt 2K-1C hypertensive rats (2K-1C) when compared to the response obtained in sham-operated (SO) rats.These results suggest that: 1) An increased blood pressure, per se, is not a determinating factor for exaggerated natriuresis.2) Rise in blood pressure and exaggerated natriuresis may be related through a common mechanism in Doca-salt hypertension.