Effects of selective and non-selective beta 1-blockade on renin secretion in the isolated rat kidney
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22)
Published:
1989-06-01
Keywords:
Adrenergic, Adrenergic beta-Antagonists/classification/pharmacology, Animals, Inbred Strains, Isoproterenol/antagonists and inhibitors/pharmacology, Kidney/drug effects/metabolism, Male, Metoprolol/pharmacology, Practolol/pharmacology, Propranolol/pharmacology, Rats, Rats/physiology, Receptors, Renin/metabolism, Secretory Rate/drug effects, Species Specificity, beta/classification/drug effects/physiology, Renin secretion, beta-Adrenoceptor
How to Cite
Effects of selective and non-selective beta 1-blockade on renin secretion in the isolated rat kidney. (1989). Revista Española De Fisiología, 45(2), 195-198. https://revistas.unav.edu/index.php/ref/article/view/46904
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Abstract
The participation of beta 1-adrenoceptor on renin secretion was studied in perfused rat kidney.Administration of propranolol, inhibited the renin release mediated by isoproterenol.Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion.These results suggest that the for isoproterenol-induced renin release in rats is a beta 1-type adrenoceptor.
Keywords:
Adrenergic, Adrenergic beta-Antagonists/classification/pharmacology, Animals, Inbred Strains, Isoproterenol/antagonists and inhibitors/pharmacology, Kidney/drug effects/metabolism, Male, Metoprolol/pharmacology, Practolol/pharmacology, Propranolol/pharmacology, Rats, Rats/physiology, Receptors, Renin/metabolism, Secretory Rate/drug effects, Species Specificity, beta/classification/drug effects/physiology, Renin secretion, beta-Adrenoceptor
Authors
J.M. Haro
F. Vargas
M.A. Castillo
L. García-Torres
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