Characterization of histaminergic receptors in the urinary bladder of sheep

Abstract
The effect of histamine was studied simultaneously on isolated smooth muscle preparations obtained from the body and base of the bladder of sheep.The histamine had a contractile effect mediated specifically through H1 receptors.It appears that the effect of histamine is not mediated through either a cholinergic or an adrenergic mechanism.
Keywords:
Animals, Atropine/pharmacology, Autonomic Agents/pharmacology, Histamine/metabolism, Histamine/pharmacology, In Vitro Techniques, Male, Receptors, Sheep/metabolism, Triprolidine/pharmacology, Urinary Bladder/drug effects/metabolism
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