Characterization of histaminergic receptors in the urinary bladder of sheep

S. Benedito
G. Costa
L. Rivera
A. García-Sacristán
56

Abstract

The effect of histamine was studied simultaneously on isolated smooth muscle preparations obtained from the body and base of the bladder of sheep.The histamine had a contractile effect mediated specifically through H1 receptors.It appears that the effect of histamine is not mediated through either a cholinergic or an adrenergic mechanism.

Keywords:
Animals, Atropine/pharmacology, Autonomic Agents/pharmacology, Histamine/metabolism, Histamine/pharmacology, In Vitro Techniques, Male, Receptors, Sheep/metabolism, Triprolidine/pharmacology, Urinary Bladder/drug effects/metabolism

Authors

S. Benedito
G. Costa
L. Rivera
A. García-Sacristán


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