Alpha- and beta-adrenoceptors in the female dog urethra

A. García-Sacristán
C. Castilla
G. Costa
A. Labadia
57

Abstract

The existence and subtypes of alpha- and beta-adrenoceptors in the female dog urethra were studied in vivo and in vitro by means of agonist and antagonist drugs.Noradrenaline, phenylephrine and B-HT 920, stimulants of alpha, alpha-1 and alpha-2 receptors respectively, caused an increase in the urethra tonicity.Thus indicating that the contractile activity is mediated by alpha-1 and alpha-2 adrenoceptors subtypes.On the other hand, the inhibitory urethral activity is under control of beta-adrenoceptors of beta-2 subtype, since the isoprenaline relaxing action is inhibited when beta-2 receptors are blocked, whilst this effect was not observed when beta-1 receptors were blocked.This fact was proved when beta-2 receptors were stimulated with salbutamol.

Keywords:
Adrenergic, Adrenergic alpha-Agonists/pharmacology, Adrenergic alpha-Antagonists/pharmacology, Adrenergic beta-Agonists/pharmacology, Adrenergic beta-Antagonists/pharmacology, Animals, Dogs, Female, In Vitro Techniques, Muscle Contraction/drug effects, Receptors, Urethra/drug effects/physiology, alpha/drug effects/physiology, beta/drug effects/physiology

Authors

A. García-Sacristán
C. Castilla
G. Costa
A. Labadia


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