Influence of VIP on D-galactose transport across rabbit jejunum in vivo

M.J. Rodríguez-Yoldi; M.P. Arruebo; A.I. Alcalde; M.D. Murillo

M.J. Rodríguez-Yoldi

M.P. Arruebo

A.I. Alcalde

M.D. Murillo

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Published: 1988-06-01

Keywords:

Animals, Galactose/metabolism, Imines/pharmacology, Intestinal Absorption/drug effects, Intestinal Mucosa/drug effects/metabolism, Jejunum/metabolism, Male, Rabbits, Time Factors, Vasoactive Intestinal Peptide/antagonists and inhibitors/physiology

How to Cite

Influence of VIP on D-galactose transport across rabbit jejunum in vivo. (1988). Revista Española De Fisiología, 44(2), 127-130. https://revistas.unav.edu/index.php/ref/article/view/47206

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Abstract

D-galactose absorption during 1 min perfusion periods was not affected by the presence of 10(-7)-10(-8) M VIP in the sugar solution, but exposure of mucosa to VIP for 5 min inhibited sugar absorption in the subsequent periods of perfusion.This inhibition is reversed after washing with saline solution.The effect of VIP disappeared when 10(-06) M RMI 12330A was added to the incubation solution together with 10(-7) M VIP and 1 mM D-galactose solution.These results suggest the existence of VIP receptors on the brush border membrane.The action of VIP could be mediated through the cAMP system.

Keywords:

Animals, Galactose/metabolism, Imines/pharmacology, Intestinal Absorption/drug effects, Intestinal Mucosa/drug effects/metabolism, Jejunum/metabolism, Male, Rabbits, Time Factors, Vasoactive Intestinal Peptide/antagonists and inhibitors/physiology