Depressed lymphoproliferative response in mixed leukocyte reaction after Mis-locus alloimmunization

R. Solana
M.C. Alonso
M. de la Fuente
J.A. Paniagua
R. Rojas
J. Peña
43

Abstract

The proliferation of BALB/C lymphocytes preimmunized with Mis or H-2 incompatible cells in response to alloantigens was studied.The results show that preimmunization with Mis-incompatible spleen cells inhibits the lymphoproliferative response against alloantigens whereas preimmunization with H-2 incompatible spleen cells enhances it.It is suggested that Mis coded determinants activate suppressor mechanisms responsible for the unresponsiveness of these preimmunized lymphocytes against alloantigens.

Keywords:
Lymphocyte Activation, Animals, H-2 Antigens/immunology, Histocompatibility Antigens/immunology, Homologous, Immunization, Inbred BALB C/immunology, Inbred CBA/immunology, Inbred DBA/immunology, Isoantigens/immunology, Lymphocyte Culture Test, Lymphocyte Transfusion, Male, Mice, Mice/immunology, Mixed, Transplantation, Mls-Locus, MLC

Authors

R. Solana
M.C. Alonso
M. de la Fuente
J.A. Paniagua
R. Rojas
J. Peña


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