Depressed lymphoproliferative response in mixed leukocyte reaction after Mis-locus alloimmunization
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22)
Published:
1984-03-01
Keywords:
Lymphocyte Activation, Animals, H-2 Antigens/immunology, Histocompatibility Antigens/immunology, Homologous, Immunization, Inbred BALB C/immunology, Inbred CBA/immunology, Inbred DBA/immunology, Isoantigens/immunology, Lymphocyte Culture Test, Lymphocyte Transfusion, Male, Mice, Mice/immunology, Mixed, Transplantation, Mls-Locus, MLC
How to Cite
Depressed lymphoproliferative response in mixed leukocyte reaction after Mis-locus alloimmunization. (1984). Revista Española De Fisiología, 40(1), 1-4. https://revistas.unav.edu/index.php/ref/article/view/47297
44
Abstract
The proliferation of BALB/C lymphocytes preimmunized with Mis or H-2 incompatible cells in response to alloantigens was studied.The results show that preimmunization with Mis-incompatible spleen cells inhibits the lymphoproliferative response against alloantigens whereas preimmunization with H-2 incompatible spleen cells enhances it.It is suggested that Mis coded determinants activate suppressor mechanisms responsible for the unresponsiveness of these preimmunized lymphocytes against alloantigens.
Keywords:
Lymphocyte Activation, Animals, H-2 Antigens/immunology, Histocompatibility Antigens/immunology, Homologous, Immunization, Inbred BALB C/immunology, Inbred CBA/immunology, Inbred DBA/immunology, Isoantigens/immunology, Lymphocyte Culture Test, Lymphocyte Transfusion, Male, Mice, Mice/immunology, Mixed, Transplantation, Mls-Locus, MLC
Authors
R. Solana
M.C. Alonso
M. de la Fuente
J.A. Paniagua
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