Requirement of macrophage metabolic activity for T-lymphocyte activation

R. Solana
M. Santamaría
M. de la Fuente
J. Peña
52

Abstract

It has been recently demonstrated that macrophages are necessary accessory cells for T-lymphocyte activation by antigens, mitogens and allogenic cells.This paper shows the function of metabolically inactive macrophages in the activation of T-lymphocytes by phytohemagglutinin (PHA).Macrophages inactivated by mitomycin C are unable to collaborate with T-lymphocytes in the development of the proliferative response to PHA indicating that the role of the macrophage in T-lymphocyte activation by mitogens goes beyond insolubilizing it or rendering it more stimulatory by another passive mechanism.

Keywords:
Lymphocyte Activation/drug effects, Animals, Cells, Cultured, Inbred CBA, Macrophages/drug effects/physiology, Mice, Mitomycin, Mitomycins/pharmacology, Phytohemagglutinins/pharmacology, T-Lymphocytes/metabolism/physiology, Uridine/metabolism

Authors

R. Solana
M. Santamaría
M. de la Fuente
J. Peña


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