Arginine as competitive inhibitor of argininosuccinate synthetase from guinea pig liver

Abstract
The influence of arginine on arginosuccinate synthetase (E.C. 6.3.4.5) from guinea pig liver has been investigated. The results show a competitive inhibition by arginine with respect to the three substrates of the enzime: L-citrulline, L-aspartate and ATP.
Keywords:
Animals, Arginine/pharmacology, Argininosuccinate Synthase/antagonists and inhibitors, Aspartate Ammonia-Lyase/metabolism, Citrulline/metabolism, Guinea Pigs, Kinetics, Ligases/antagonists and inhibitors, Liver/enzymology, Male
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